For some women with few, or no ovulation, this is the mainstay of treatment. Classically this would be women with PCOS, and in uncommon circumstances, functional amenorrhea, or hypogonadotrophin hypogonadism. Ovulation induction agents such as letrozole, clomiphene citrate and FSH/LH are used to help the body produce an egg each month. The success rates per cycle is similar to natural chances once ovulation occurs. There is clear evidence in women who are ovulatory (regular periods), that these processes do not increase the pregnancy rates.

Ovulation induction can be done monitored or unmonitored. Monitored treatments allows correct timing of intercourse and reduce the risk of multiple pregnancies (twins for example). But it does increase the burden of treatment due to needing to go into the clinic for blood tests and scans.